Targeted Novel Drug Delivery System for Treatment of Glioblastoma
Glioblastoma (GB) is the most aggressive form of brain cancer and has witnessed very little clinical progress over the past few decades, in part, due to the absence of effective drug delivery strategies. The primary line of treatment for GB includes surgery, radiation therapy, and chemotherapy. Despite recent progress in brain tumor research, the survival time of GB patients after initial diagnosis is less than two years. There have been several challenges in GB drug delivery treatment due to the presence of blood-brain barrier (BBB), unexpected brain damage to normal healthy brain cells caused by surgery, and the highly heterogeneous nature of the GB cells that are resistant to many therapeutic modalities. The objective of our research proposal aims to take advantage of our proprietary Up-Conversion Nanoparticles for the treatment of GB. We engineered novel and specific UCNPs with unique dopants to enhance emission to kill GB cells, thus making it a promising theranostic system.
A new understanding of disease.
Our mission is to develop & deliver oncology, cardiovascular, and other therapies for patients with high unmet medical needs.